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4-CPPC

CAT: 0804-HY-123814-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123814-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 µM for MIF-1, MIF-2, respectively[1].
CAS Number
29553-70-6
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-cppc.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O
Molecular Formula
C14H9NO6
Molecular Weight
287.22
References & Citations
[1]Pantouris G, et al. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57 (26) :3599-3605.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic Acid
CAS Number29553-70-6
PubChem CID893698
IUPAC Name4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
Molecular FormulaC14H9NO6
Molecular Weight287.22
XLogP1.4
Topological Polar Surface Area125
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity437
SMILES
C1=CC(=CC(=C1)C(=O)O)C2=CC(=NC=C2C(=O)O)C(=O)O
InChI
InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21)
InChIKey
NBVHLJGGHJLTGM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic Acid
CAS: 29553-70-6
CID: 893698
Formula: C14H9NO6
MW: 287.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.22
XLogP31.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass287.04298701
Monoisotopic Mass287.04298701
Topological Polar Surface Area125 Ų
Heavy Atom Count21
Formal Charge0
Complexity437
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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