L-Ascorbic acid (sodium salt)

• UNSPSC Description:

  L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].

• Target Antigen:

  Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/L-Ascorbic-acid-sodium.html

• Purity:

  99.97

• Solubility:

  DMSO : 1 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O

• Molecular Weight:

  198.11

• References & Citations:

  [1]Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[2]Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.|[3]Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.|[4]Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.|[5]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[6]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.Environ Toxicol. 2021 Apr;36(4):520-529.|FASEB J. 2020 Sep;34(9):11474-11487.|Hematol Oncol. 2024 Jul;42(4):e3295.|J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.|Mil Med Res. 2020 Nov 1;7(1):52.|Anim Biotechnol. 2024 Nov;35(1):2404043.|Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.|Antioxidants (Basel). 2024 May 27.|Biochem Biophys Res Commun. 2024 Mar 15, 149770.|Biomaterials. 2024 Aug 15:313:122756.|Biomed Pharmacother. September 2022, 113558.|Bioorg Chem. 2021, 105177.|Bioorg Chem. 2024 Mar 5:146:107261.|Biosci Rep. 2019 May 21;39(5):BSR20182137.|Cancer Cell Int. 2024 May 31;24(1):192.|Cancer Cell. 2024 Apr 8;42(4):682-700.e12.|Cell Biol Toxicol. 2021 Jul 20.|Cell Cycle. 2022 Nov 12;1-18.|Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X.|Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923.|Cytotechnology. 02 October 2021.|Drug Chem Toxicol. 2023 Feb 23;1-9.|Eur J Med Chem. 2022 Jan 28;231:114151.|Fitoterapia. 2021 Jun 30;104984.|Food Funct. 2022 May 10;13(9):5089-5101.|Free Radic Biol Med. 2020 Feb 1;147:220-230.|Front Cell Dev Biol. 2022 Feb 10:10:810327.|Genes. 2024 Sep 13.|Int J Biol Macromol. 2023 Nov 17:127779.|iScience. 2024 Feb 5;27(3):109111.|IUBMB Life. 2024 Jul 16.|J Biol Chem. 2023 Nov 15:105462.|J Cell Mol Med. 2020 Apr;24(7):4212-4222.|J Cell Physiol. 2024 Feb 3.|J Mol Histol. 2024 May 27.|J Nat Prod. 2022 Jul 7.|J Neurosci Res. 2019 Dec;97(12):1689-1705. |J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.|J Sex Med. 2018 Feb;15(2):136-147. |Mol Biol Rep. 2024 Mar 14;51(1):421.|Mol Med Rep. 2019 Dec; 20(6): 4933–4942.|Nat Immunol. 2022 Dec 21.|Nigerian Journal of Scientific Research. 18 (3): 2019.|Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.|Redox Biol. 2022 Aug;54:102392.|Research Square Print. 2022 Aug.|Sci China Life Sci. 2018 Oct;61(10):1151-1167.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Launched

• CAS Number:

  134-03-2