Sulfo-SPDB

• Description:

  Sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H319

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sulfo-spdb.html

• Purity:

  95.0

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  O=C(ON1C(CCC1=O)=O)C(S(=O)(O)=O)CCSSC2=NC=CC=C2

• Molecular Formula:

  C13H14N2O7S3

• Molecular Weight:

  406.45

• Precautions:

  H302, H319

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, protect from light, stored under nitrogen

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number:

  1193111-39-5