SPDB

• Description :

  SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) [1].

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SPDB.html

• Purity :

  99.16

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(CC1)N(OC(CCCSSC2=NC=CC=C2)=O)C1=O

• Molecular Formula :

  C13H14N2O4S2

• Molecular Weight :

  326.40

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26 (11) :2261-78.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number :

  [115088-06-7]