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SPDB

CAT: 0804-HY-12448-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12448-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) [1].
CAS Number
[115088-06-7]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SPDB.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1)N(OC(CCCSSC2=NC=CC=C2)=O)C1=O
Molecular Formula
C13H14N2O4S2
Molecular Weight
326.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26 (11) :2261-78.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker

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