SPDB

• Description:

  SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) [1].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SPDB.html

• Purity:

  99.16

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CC1)N(OC(CCCSSC2=NC=CC=C2)=O)C1=O

• Molecular Formula:

  C13H14N2O4S2

• Molecular Weight:

  326.40

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26 (11) :2261-78.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number:

  [115088-06-7]