Sulfo-LC-SPDP

CAT: 0804-HY-126495-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-126495-01Size:5 mg

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Description

Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

CAS Number

150244-18-1

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sulfo-lc-spdp.html

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)CCCCCNC(CCSSC2=NC=CC=C2)=O

Molecular Formula

C18H23N3O8S3

Molecular Weight

505.59

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker; Disulfide Cleavable Linker

Chemical Information

Sulphosuccinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate

CAS Number	150244-18-1
PubChem CID	4588468
IUPAC Name	2,5-dioxo-1-[6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoyloxy]pyrrolidine-3-sulfonic acid
Molecular Formula	C18H23N3O8S3
Molecular Weight	505.6
XLogP	0.6
Topological Polar Surface Area	219
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	14
Heavy Atom Count	32
Formal Charge	0
Complexity	787

SMILES

C1C(C(=O)N(C1=O)OC(=O)CCCCCNC(=O)CCSSC2=CC=CC=N2)S(=O)(=O)O

InChI

InChI=1S/C18H23N3O8S3/c22-14(8-11-30-31-15-6-3-5-10-20-15)19-9-4-1-2-7-17(24)29-21-16(23)12-13(18(21)25)32(26,27)28/h3,5-6,10,13H,1-2,4,7-9,11-12H2,(H,19,22)(H,26,27,28)

InChIKey

ASNTZYQMIUCEBV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 150244-18-1

CID: 4588468

Formula: C18H23N3O8S3

MW: 505.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	505.6
XLogP3	0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	14
Exact Mass	505.06472822
Monoisotopic Mass	505.06472822
Topological Polar Surface Area	219 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	787
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
HY-133543	SPDP-sulfo
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HY-D0799A	Sulfo-NHS-LC-Biotin
HY-D0799-01	Sulfo-NHS-LC-Biotin (sodium)
HY-129370	SPDB-sulfo
HY-101151-01	Sulfo-SPDB
HY-100216-01	SPDP
HY-131084	DMAC-SPDB-sulfo
HY-136291	Sulfo-SPDB-DGN462

Alternative Products

Catalog	Name
BA2537-10	Sulfo-LC-SPDP
21810024-1	Sulfo-NHS LC SPDP
571613	Sulfo-LC-SPDP Crosslinker
MBS5799222	SPDP-sulfo
21810011-1	NHS LC SPDP
T15724-01	LC-PEG8-SPDP
571604	LC-SPDP Crosslinker
sc-397283	Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine)
BUP20307-01	Sulfo-NHS-LC-LC-Biotin
abx185570-01	sulfo-LC-(+)-Biotin

Sulfo-LC-SPDP

Chemical Information

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