SPDB-DM4

• Description :

  SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.

• UNSPSC :

  12352203

• Target :

  Drug-Linker Conjugates for ADC

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SPDB-DM4.html

• Purity :

  99.18

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1

• Molecular Formula :

  C46H63ClN4O14S2

• Molecular Weight :

  995.59

• References & Citations :

  [1]Puja Sapra, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Investig Drugs. 2011 Aug;20 (8) :1131-49.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, protect from light, stored under nitrogen

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Maytansinoids

• CAS Number :

  [1626359-62-3]