Wf-516

• Description:

  Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Wf-516.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H] (COC1=C2C=C (C3=NN=C (C) O3) OC2=CC=C1) CN (CC4) CCC4C5=CC=C (Cl) C (Cl) =C5

• Molecular Formula:

  C25H25Cl2N3O4

• Molecular Weight:

  502.39

• References & Citations:

  [1]El Mansari M, et al. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376 (5) :351-61. Epub 2007 Nov 30.|[2]Saijo T, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS One. 2012;7 (8) :e42589.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

• CAS Number:

  310392-94-0