Wf-516

CAT: 0804-HY-19417ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19417ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.
CAS Number
[310392-94-0]
UNSPSC
12352005
Target
5-HT Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Wf-516.html
Solubility
10 mM in DMSO
Smiles
O[C@H](COC1=C2C=C(C3=NN=C(C)O3)OC2=CC=C1)CN(CC4)CCC4C5=CC=C(Cl)C(Cl)=C5
Molecular Formula
C25H25Cl2N3O4
Molecular Weight
502.39
References & Citations
[1]El Mansari M, et al. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376 (5) :351-61. Epub 2007 Nov 30.|[2]Saijo T, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS One. 2012;7 (8) :e42589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

Related Products

CatalogName
HY-155164WF-3681
HY-113853WF-10129
HY-118837WF-536
HY-117614WF-210
HY-133551-01WF-47-JS03
HY-129408SGE-516
HY-125984Syn-516
HY-W952983CRBN ligand-516
HY-101809ACNS 5161
HY-43643-01DC-5163

Alternative Products

CatalogName
MBS5767856Wf-516
MBS5813598WF 2421
MBS5801764WF 3681
MBS5776055WF 10129
MF-0046899-01WF-210
MF-0049018-01WF 11605
MBS387205-01WF 11899A
BA8999-10WF-47-JS03
MBS133397CX-516
M10645-01CKD-516

Popular Products