SGE-516

CAT: 0804-HY-129408Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-129408Size:1 Each
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Description
SGE-516 is a neuroactive steroid that is a potent positive allosteric modulator of synaptic and extra-synaptic GABAA receptors. SGE-516 has anticonvulsant activity[1].
CAS Number
[1430064-74-6]
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sge-516.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@H](C(CN3N=CC=N3)=O)CC[C@@]1([H])[C@]4([H])CC[C@]5([H])C[C@](C)(O)CC[C@]5([H])[C@@]4([H])CC2
Molecular Formula
C23H35N3O2
Molecular Weight
385.54
References & Citations
[1]Hawkins NA, et al. The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model. Sci Rep. 2017 Nov 10;7 (1) :15327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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