Syn-516

• Description :

  Syn-516 is an inhibitor of α-synuclein (α-Syn) . Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia[1][2].

• UNSPSC :

  12352005

• Target :

  α-synuclein

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  NC1=NC(CSC2=NN=NN2C3=C4C=CC=CC4=CC=C3)=NC(N(C)C)=N1

• Molecular Formula :

  C17H17N9S

• Molecular Weight :

  379.44

• References & Citations :

  [1]Cahill CM, et al. Alpha-synuclein in alcohol use disorder, connections with Parkinson’s disease and potential therapeutic role of 5’untranslated region-directed small molecules. Biomolecules. 2020 Oct 21;10 (10) :1465.|[2]Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory. 2020 Sep 1;27 (9) :395-413.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [695209-67-7]