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Syn-516

CAT: 0804-HY-125984Size: 1 EachDry Ice: NoHazardous: No
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Description
Syn-516 is an inhibitor of α-synuclein (α-Syn) . Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia[1][2].
CAS Number
695209-67-7
UNSPSC
12352005
Target
α-synuclein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
NC1=NC(CSC2=NN=NN2C3=C4C=CC=CC4=CC=C3)=NC(N(C)C)=N1
Molecular Formula
C17H17N9S
Molecular Weight
379.44
References & Citations
[1]Cahill CM, et al. Alpha-synuclein in alcohol use disorder, connections with Parkinson’s disease and potential therapeutic role of 5’untranslated region-directed small molecules. Biomolecules. 2020 Oct 21;10 (10) :1465.|[2]Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory. 2020 Sep 1;27 (9) :395-413.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N2,N2-dimethyl-6-[[[1-(1-naphthalenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamine

N2,N2-dimethyl-6-[[[1-(1-naphthalenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamine is a member of naphthalenes.

CAS Number695209-67-7
PubChem CID1517919
IUPAC Name2-N,2-N-dimethyl-6-[(1-naphthalen-1-yltetrazol-5-yl)sulfanylmethyl]-1,3,5-triazine-2,4-diamine
Molecular FormulaC17H17N9S
Molecular Weight379.4
XLogP3
Topological Polar Surface Area137
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity481
SMILES
CN(C)C1=NC(=NC(=N1)N)CSC2=NN=NN2C3=CC=CC4=CC=CC=C43
InChI
InChI=1S/C17H17N9S/c1-25(2)16-20-14(19-15(18)21-16)10-27-17-22-23-24-26(17)13-9-5-7-11-6-3-4-8-12(11)13/h3-9H,10H2,1-2H3,(H2,18,19,20,21)
InChIKey
KEGAOGGMAQQKFO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2,N2-dimethyl-6-[[[1-(1-naphthalenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamine
CAS: 695209-67-7
CID: 1517919
Formula: C17H17N9S
MW: 379.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.4
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass379.13276275
Monoisotopic Mass379.13276275
Topological Polar Surface Area137 Ų
Heavy Atom Count27
Formal Charge0
Complexity481
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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