PROTAC BRD4 Degrader-22

PROTAC BRD4 Degrader-22

• CAS Number: 3032850-37-3
• UNSPSC Description: PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based BRD4 degrader, with a pDC50 (MOLT4, 24 h) of 9.2[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-brd4-degrader-22.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C=C1OC)N2CCC(CC2)CNC(C[C@@H]3N=C(C4=C(N5C(C)=NN=C35)SC(C)=C4C)C6=CC=C(C=C6)Cl)=O)NC(C(N7)=O)CCC7=O
• Molecular Weight: 757.30
• References & Citations: [1]Christian Steinebach, et al. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J Med Chem. 2023 Oct 30.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported