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PROTAC BRD4 Degrader-22

CAT: 0804-HY-155393Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155393Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based BRD4 degrader, with a pDC50 (MOLT4, 24 h) of 9.2[1].
CAS Number
3032850-37-3
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1OC)N2CCC(CC2)CNC(C[C@@H]3N=C(C4=C(N5C(C)=NN=C35)SC(C)=C4C)C6=CC=C(C=C6)Cl)=O)NC(C(N7)=O)CCC7=O
Molecular Formula
C38H41ClN8O5S
Molecular Weight
757.30
References & Citations
[1]Christian Steinebach, et al. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J Med Chem. 2023 Oct 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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