RP 67580

CAT: 0804-HY-108483-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108483-01Size:5 mg
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Description
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1].
CAS Number
[135911-02-3]
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rp-67580.html
Purity
97.4
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2([H])CN(C(CC3=CC=CC=C3OC)=N)C[C@@]2([H])C(C4=CC=CC=C4)(C5=CC=CC=C5)CC1
Molecular Formula
C29H30N2O2
Molecular Weight
438.56
References & Citations
[1]Garret C, et al. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci U S A. 1991 Nov 15;88 (22) :10208-12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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