Rp-cAMPS

• Description:

  Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

• UNSPSC:

  12352005

• Target:

  PKA

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rp-camps.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H] (O[C@@]2 ([H]) [C@@]1 ([H]) O[P@@] (OC2) (S) =O) N3C4=C (C (N) =NC=N4) N=C3

• Molecular Formula:

  C10H12N5O5PS

• Molecular Weight:

  345.27

• References & Citations:

  [1] Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'- (cyclic) phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251 (3) :757-62.|[2]Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26.|[3]Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36 (3) :730-6.|[4]Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265 (18) :10484-91.|[5]Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259 (16) :10020-4.|[6]R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142 (2) :255-60.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Theranostics. 2021 Mar 24;11 (12) :5650-5674.|Cell Commun Signal. 2024 Jun 3;22 (1) :307.|Nat Commun. 2025 Jul 1;16 (1) :5425.|Research Square Preprint. 2024 Apr 9.

• CAS Number:

  73208-40-9