RP-832c

CAT: 0804-HY-P11107-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P11107-01Size:1 mg
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Description
RP-832c is a synthetic analogue of host defense peptides (HDP), targeting the mannose receptor CD206 on the surface of M2 polarized macrophages (Kd = 3.5 μM) . RP-832c binding to CD206 induces a significant conformational change in the receptor, activating signaling pathways that lead to rapid apoptosis and repolarization of CD206-positive M2 macrophages to an M1 phenotype. RP-832c treatment significantly reduces CD206 gene expression in M2 macrophages while transiently increasing expression of TNF-α, a marker for M1 macrophages. RP-832c is used for the studies of T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF) [1][2].
CAS Number
[2375823-45-1]
UNSPSC
12352209
Target
Apoptosis; TNF Receptor
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
98.16
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=CC=C3)C(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C68H94N20O11
Molecular Weight
1367.60
References & Citations
[1]Carla Portocarrero, et al; Targeting Immunosuppressive Macrophages in the Cutaneous T-Cell Lymphoma Microenvironment. Blood 2022; 140 (Supplement 1) : 3146–3147.|[2]Ghebremedhin A, et al. A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice. Cells. 2023 Apr 26;12 (9) :1254.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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