RP-69758

• Description :

  RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB) /gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261) -induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research[1].

• CAS Number :

  [138562-23-9]

• UNSPSC :

  12352005

• Target :

  Cholecystokinin Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease; Inflammation/Immunology

• Smiles :

  O=C(CC1=CC=CC(NC(NCC(N(C2=CC=CC=C2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)=C1)O

• Molecular Formula :

  C26H26N4O5

• Molecular Weight :

  474.51

• References & Citations :

  [1]Bertrand P, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262 (3) :233-45.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported