RP-69758

• Description:

  RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB) /gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261) -induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research[1].

• UNSPSC:

  12352005

• Target:

  Cholecystokinin Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease; Inflammation/Immunology

• Smiles:

  O=C (CC1=CC=CC (NC (NCC (N (C2=CC=CC=C2) CC (N (C3=CC=CC=C3) C) =O) =O) =O) =C1) O

• Molecular Formula:

  C26H26N4O5

• Molecular Weight:

  474.51

• References & Citations:

  [1]Bertrand P, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262 (3) :233-45.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  138562-23-9