PROTAC BRAF-V600E degrader-1
CAT:
804-HY-137487-02
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC BRAF-V600E degrader-1
- CAS Number: 2417296-84-3
- UNSPSC Description: PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth[1].
- Target Antigen: PROTACs; Raf
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-braf-v600e-degrader-1.html
- Smiles: CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(C(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)CC5)C)=CC=C42)=C1F)=O
- Molecular Weight: 1001.07
- References & Citations: [1]Han XR, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.
- Shipping Conditions: Room Temperature