PROTAC NCOA4 degrader-1

• UNSPSC Description:

  PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B))[1].

• Target Antigen:

  Ferroptosis; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/protac-ncoa4-degrader-1.html

• Smiles:

  CN1CCN(C2=CC3=C(N=C(C4=CC(N5CCC6=CC(OCCOCCOCCOCCNC(CCCC(N[C@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)=O)=O)=O)=CC=C6C5)=CC=C4)N3)C=C2)CC1

• Molecular Weight:

  1141.43

• References & Citations:

  [1]Jian’ai Ji, et al. Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition. Journal of Medicinal Chemistry 2024 67 (15), 12521-12533.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported