Products for Research Use Only
RegisterLogin

B-Raf IN 19

CAT: 0804-HY-155942Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-155942Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
B-Raf IN 19 (compound 31) is a BRAF inhibitor that inhibits BRAF (WT) and BRAF (V600E) (IC50: 0.57 μM and 0.28 μM, respectively) . B-Raf IN 19 inhibits MAPK signaling in melanoma cells[1].
CAS Number
708218-62-6
UNSPSC
12352005
Target
P38 MAPK; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-19.html
Smiles
O=S(NC1=CC(SC2=CC=CC=C2)=C(C3=C1C=CC=C3)O)(C4=CC=CS4)=O
Molecular Formula
C20H15NO3S3
Molecular Weight
413.53
References & Citations
[1]Qin J, et al. Identification of a novel family of BRAF (V600E) inhibitors. J Med Chem. 2012 Jun 14;55 (11) :5220-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf

Chemical Information

N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)thiophene-2-sulfonamide
CAS Number708218-62-6
PubChem CID2133813
IUPAC NameN-(4-hydroxy-3-phenylsulfanylnaphthalen-1-yl)thiophene-2-sulfonamide
Molecular FormulaC20H15NO3S3
Molecular Weight413.5
XLogP5.4
Topological Polar Surface Area128
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity588
SMILES
C1=CC=C(C=C1)SC2=C(C3=CC=CC=C3C(=C2)NS(=O)(=O)C4=CC=CS4)O
InChI
InChI=1S/C20H15NO3S3/c22-20-16-10-5-4-9-15(16)17(21-27(23,24)19-11-6-12-25-19)13-18(20)26-14-7-2-1-3-8-14/h1-13,21-22H
InChIKey
ANWROCYWIBTMKJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)thiophene-2-sulfonamide
CAS: 708218-62-6
CID: 2133813
Formula: C20H15NO3S3
MW: 413.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight413.5
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass413.02140686
Monoisotopic Mass413.02140686
Topological Polar Surface Area128 Ų
Heavy Atom Count27
Formal Charge0
Complexity588
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-18227-01B-Raf IN 1
HY-77113-01B-Raf IN 11
HY-142820B-Raf IN 5
HY-150250B-Raf IN 13
HY-158027B-Raf IN 17
HY-156590-01B-Raf IN 16
HY-153914B-Raf IN 14
HY-147853B-Raf IN 8
HY-120676-01B-Raf IN 18
HY-147852B-Raf IN 7

Alternative Products

CatalogName
MBS8533828-01B Raf
331907-01Raf-B
398333-01B-RAF
345587-01Raf-B discontinued
T60727-01B-Raf IN 8
T1845-01B-Raf IN 1
T64116-01B-Raf IN 5
398335-01B-RAF discontinued
DF3095-01B Raf Antibody
MBS8587265-01B-RAF Antibody

Popular Products