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B-Raf IN 7

CAT: 0804-HY-147852Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147852Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].
CAS Number
2477725-07-6
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N)N(C2=CC=C(C(CC3)=NNC3=O)C=C2)N=N1)OCC
Molecular Formula
C15H16N6O3
Molecular Weight
328.33
References & Citations
[1]Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf

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