L-Ascorbic acid 2-phosphate

• Description :

  L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs) . L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

• CAS Number :

  [23313-12-4]

• Product Name Alternative :

  2-Phospho-L-ascorbic acid; LAA2P

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Phosphatase; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/l-ascorbic-acid-2-phosphate.html

• Solubility :

  1 M HCl : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC([C@H](O1)[C@H](CO)O)=C(OP(O)(O)=O)C1=O

• Molecular Formula :

  C6H9O9P

• Molecular Weight :

  256.10

• References & Citations :

  [1]Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52 (12) :8711-7.|[2]Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266 (15) :9997-10003.|[3]Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4 (1) :17.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• Citation 01 :

  Adv Mater. 2025 Jul 14:e2501306.|Adv Sci (Weinh) . 2024 Dec;11 (46) :e2400502.|Adv Sci (Weinh) . 2025 Nov 21:e08472.|Biomolecules. 2025 Nov 19;15 (11) :1623.|Cell Transplant. 2025 Jan-Dec:34:9636897251376125.|Autophagy. 2023 Feb;19 (2) :632-643.|Eng Life Sci. 2025 Oct 13;25 (10) :e70050.|Food Hydrocoll. 2026 Mar.