L-Ascorbic acid 2-phosphate

• UNSPSC Description:

  L-ascorbic?acid?2-phosphate (2-Phospho-L-ascorbic acid) is a?long-acting?vitamin?C?derivative?that can stimulate collagen formation and expression[1]. L-ascorbic?acid?2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic?acid?2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

• Target Antigen:

  Endogenous Metabolite; Phosphatase; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-ascorbic-acid-2-phosphate.html

• Solubility:

  1 M HCL : 25 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC([C@H](O1)[C@H](CO)O)=C(OP(O)(O)=O)C1=O

• Molecular Weight:

  256.10

• References & Citations:

  [1]Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7.|[2]Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003.|[3]Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17.Adv Sci (Weinh). 2024 Oct 17:e2400502.|Autophagy. 2022 Jul 4.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  23313-12-4