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RIPK1-IN-26

CAT: 0804-HY-162928Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162928Size:1 Each
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Description
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders[1].
CAS Number
2252271-96-6
UNSPSC
12352101
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ripk1-in-26.html
Smiles
O=C(C(C)(C)CC)N1CCOC2=CC=C(F)C=C2C1
Molecular Formula
C15H20FNO2
Molecular Weight
265.32
References & Citations
[1]Luo T, et al. Design, synthesis, and preclinical evaluation of 11C/18F-labeled inhibitors for RIPK1 PET imaging. Eur J Med Chem. 2024 Sep 6;279:116851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

US11203600, Example 32
CAS Number2252271-96-6
PubChem CID142476029
IUPAC Name1-(7-fluoro-3,5-dihydro-2H-1,4-benzoxazepin-4-yl)-2,2-dimethylbutan-1-one
Molecular FormulaC15H20FNO2
Molecular Weight265.32
XLogP2.8
Topological Polar Surface Area29.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity332
SMILES
CCC(C)(C)C(=O)N1CCOC2=C(C1)C=C(C=C2)F
InChI
InChI=1S/C15H20FNO2/c1-4-15(2,3)14(18)17-7-8-19-13-6-5-12(16)9-11(13)10-17/h5-6,9H,4,7-8,10H2,1-3H3
InChIKey
JTGFKPBXGASRSI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of US11203600, Example 32
CAS: 2252271-96-6
CID: 142476029
Formula: C15H20FNO2
MW: 265.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.32
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass265.14780704
Monoisotopic Mass265.14780704
Topological Polar Surface Area29.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity332
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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