SB 452533

• Description:

  SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H318, H410

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sb-452533.html

• Purity:

  99.11

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCN(CC)C1=CC=CC(C)=C1)NC2=CC=CC=C2Br

• Molecular Formula:

  C18H22BrN3O

• Molecular Weight:

  376.29

• Precautions:

  H302, H318, H410

• References & Citations:

  [1]Harshad K Rami, et al. Discovery of small molecule antagonists of TRPV1. Bioorg Med Chem Lett. 2004 Jul 16;14 (14) :3631-4.|[2]Parisa Vahidi Ferdowsi, et al. TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells. Cells. 2021 Jun 21;10 (6) :1560.|[3]Lin Ming Lu, et al. Effect of small dose capsaicin for treatment of pulmonary fibrosis in mice and its mechanism. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 May;36 (3) :216-222.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [459429-39-1]