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(RS) -MCPG

CAT: 0804-HY-100371-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100371-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(RS) -MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS) -MCPG blocks theta-burst stimulation (TBS) -induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].
CAS Number
146669-29-6
Product Name Alternative
Alpha-MCPG
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_RS_-MCPG.html
Purity
99.05
Solubility
1M NaOH : 100 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : 6 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; heat to 80°C)
Smiles
CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
Molecular Formula
C10H11NO4
Molecular Weight
209.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10 (9) :e0138215.|[2]Fiona Yeuk-Lun Choi, et al. The effects of (RS) -MCPG on amphetamine-induced sensitization in neonatal rats.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR

Chemical Information

alpha-Methyl-4-carboxyphenylglycine

glutamate receptor antagonist

CAS Number146669-29-6
PubChem CID1222
IUPAC Name4-(1-amino-1-carboxyethyl)benzoic acid
Molecular FormulaC10H11NO4
Molecular Weight209.20
XLogP-2
Topological Polar Surface Area101
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity271
SMILES
CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
InChI
InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
InChIKey
DNCAZYRLRMTVSF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of alpha-Methyl-4-carboxyphenylglycine
CAS: 146669-29-6
CID: 1222
Formula: C10H11NO4
MW: 209.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight209.20
XLogP3-2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass209.06880783
Monoisotopic Mass209.06880783
Topological Polar Surface Area101 Ų
Heavy Atom Count15
Formal Charge0
Complexity271
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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