(RS) -MCPG

• Description:

  (RS) -MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS) -MCPG blocks theta-burst stimulation (TBS) -induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

• Product Name Alternative:

  Alpha-MCPG

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_RS_-MCPG.html

• Purity:

  99.05

• Solubility:

  1M NaOH : 100 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : 6 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; heat to 80°C)

• Smiles:

  CC (C (O) =O) (N) C1=CC=C (C (O) =O) C=C1

• Molecular Formula:

  C10H11NO4

• Molecular Weight:

  209.20

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10 (9) :e0138215.|[2]Fiona Yeuk-Lun Choi, et al. The effects of (RS) -MCPG on amphetamine-induced sensitization in neonatal rats.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR

• CAS Number:

  146669-29-6