(RS) -MCPG

• Description :

  (RS) -MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS) -MCPG blocks theta-burst stimulation (TBS) -induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

• Product Name Alternative :

  Alpha-MCPG

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/_RS_-MCPG.html

• Purity :

  99.05

• Solubility :

  1M NaOH : 100 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : 6 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; heat to 80°C)

• Smiles :

  CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1

• Molecular Formula :

  C10H11NO4

• Molecular Weight :

  209.20

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10 (9) :e0138215.|[2]Fiona Yeuk-Lun Choi, et al. The effects of (RS) -MCPG on amphetamine-induced sensitization in neonatal rats.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR

• CAS Number :

  [146669-29-6]