(RS)-MCPG

• UNSPSC Description:

  (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

• Target Antigen:

  mGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_RS_-MCPG.html

• Purity:

  99.05

• Solubility:

  1M NaOH : 100 mg/mL (ultrasonic;adjust pH to 10 with NaOH)|DMSO : 6 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic;heat to 80°C)

• Smiles:

  CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1

• Molecular Weight:

  209.201

• References & Citations:

  [1]Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10(9):e0138215.|[2]Fiona Yeuk-Lun Choi, et al. The effects of (RS)-MCPG on amphetamine-induced sensitization in neonatal rats.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  146669-29-6