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(RS) -4C3HPG

CAT: 0804-HY-100840ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100840ASize:1 Each
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Description
(RS) -4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS) -4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model[1][2].
CAS Number
134052-66-7
Product Name Alternative
4-Carboxy-3-hydroxyphenylglycine
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-4c3hpg.html
Smiles
O=C(O)C(N)C1=CC=C(C(O)=O)C(O)=C1
Molecular Formula
C9H9NO5
Molecular Weight
211.17
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Gerber U, et al. 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus. Eur J Pharmacol. 1992 Oct 20;221 (2-3) :401-2. |[2]Henrich-Noack P, et al. The mGlu receptor ligand (S) -4C3HPG protects neurons after global ischaemia in gerbils. Neuroreport. 1998 Apr 20;9 (6) :985-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR2; mGluR3

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