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(S) -MCPG

CAT: 0804-HY-100406-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100406-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -MCPG ((+) -MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS) -MCPG. (S) -MCPG can be used for the study of the function of mGluRs in spatial learning[2].
CAS Number
150145-89-4
Product Name Alternative
(+) -MCPG
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_S_-MCPG.html
Purity
99.61
Solubility
1M NaOH : 22 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; adjust pH to 13 with 1M NaOH)
Smiles
OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O
Molecular Formula
C10H11NO4
Molecular Weight
209.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39 (7) :1130-7.|[2]F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35 (11) :1557-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR

Chemical Information

(S)-alpha-methyl-4-carboxyphenylglycine

(S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. It has a role as a metabotropic glutamate receptor antagonist.

CAS Number150145-89-4
PubChem CID446355
IUPAC Name4-[(1S)-1-amino-1-carboxyethyl]benzoic acid
Molecular FormulaC10H11NO4
Molecular Weight209.20
XLogP-2
Topological Polar Surface Area101
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity271
SMILES
C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
InChI
InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
InChIKey
DNCAZYRLRMTVSF-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of (S)-alpha-methyl-4-carboxyphenylglycine
CAS: 150145-89-4
CID: 446355
Formula: C10H11NO4
MW: 209.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight209.20
XLogP3-2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass209.06880783
Monoisotopic Mass209.06880783
Topological Polar Surface Area101 Ų
Heavy Atom Count15
Formal Charge0
Complexity271
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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