(S) -MCPG

• Description :

  (S) -MCPG ((+) -MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS) -MCPG (HY-100371) [1]. (S) -MCPG can be used for the study of the function of mGluRs in spatial learning[2].

• Product Name Alternative :

  (+) -MCPG

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/_S_-MCPG.html

• Purity :

  99.61

• Solubility :

  1M NaOH : 22 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; adjust pH to 13 with 1M NaOH)

• Smiles :

  OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O

• Molecular Formula :

  C10H11NO4

• Molecular Weight :

  209.20

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39 (7) :1130-7.|[2]F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35 (11) :1557-65.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR

• CAS Number :

  [150145-89-4]