(S) -MCPG

• Description:

  (S) -MCPG ((+) -MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS) -MCPG (HY-100371) [1]. (S) -MCPG can be used for the study of the function of mGluRs in spatial learning[2].

• Product Name Alternative:

  (+) -MCPG

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_S_-MCPG.html

• Purity:

  99.61

• Solubility:

  1M NaOH : 22 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; adjust pH to 13 with 1M NaOH)

• Smiles:

  OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O

• Molecular Formula:

  C10H11NO4

• Molecular Weight:

  209.20

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39 (7) :1130-7.|[2]F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35 (11) :1557-65.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR

• CAS Number:

  [150145-89-4]