RS 09

• Description:

  RS 09 is an LPS (HY-D1056) peptide mimic and TLR4 agonist. RS 09 can bind to TLR-4 and activate NF-κB. RS 09 can function as an adjuvant in vivo, enhancing the antigen-specific immune response[1].

• UNSPSC:

  12352209

• Target:

  NF-κB; Toll-like Receptor (TLR)

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rs-09.html

• Purity:

  99.88

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  OC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](N)C)=O)=O)=O)CC3=CNC=N3)=O)C)=O)CC(C)C)=O)CO)=O

• Molecular Formula:

  C31H49N9O9

• Molecular Weight:

  691.78

• References & Citations:

  [1]Shanmugam A, et al. Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. PLoS One. 2012;7 (2) :e30839.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  TLR4

• Citation 01:

  ACS Chem Neurosci. 2025 Mar 5;16 (5) :968-980.|Bioact Mater. 2022 Nov 9:23:69-79.|Biochim Biophys Acta Mol Basis Dis. 2025 Feb 8;1871 (3) :167710.|Cell Signal. 2025 Sep 18:136:112140.|Hepatology. 2025 Nov 7.|J Ethnopharmacol. 2025 Oct 15;355 (Pt B) :120749.|Mol Cell Biol. 2025 Nov 25:1-12.|Mol Neurobiol. 2025 May;62 (5) :6070-6087.|Neurochem Int. 2025 Feb 4:105940.|NPJ Parkinsons Dis. 2025 Nov 28;11 (1) :342.|Phytomedicine. 2024 Dec 3:136:156314.|Clin Exp Hypertens. 2025 Dec;47 (1) :2486829.|Int Immunopharmacol. 2024 May 9:134:112188.|J Adv Res. 2024 Nov 14:S2090-1232 (24) 00536-8.|Phytomedicine. 2022 Oct:105:154360.|Placenta. 2025 Jan 3:160:89-99.

• CAS Number:

  [1449566-36-2]