RecombinantIL-21, Mouse

CAT: 0384-BK0099-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0099-01Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. The IL-21 receptor is highly expressed on CD4+ and CD8+ B cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21regulates the production of IgG1 and IgE by B cells, and diminishes the severity of allergy and asthma. In some cases, IL-21 induces B cell apoptosis. Other roles of IL-21 include regulation of the innate immune system, implication in autoimmunity, and antitumor activity.Recombinant mouse interleukin-21 (IL-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 123 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 < 1 ng/mL, measured by its ability to stimulate the proliferation of human ANBL-6 cells, corresponding to a specific activity of > 1.0x 10ˆ6 units/mg.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
15.1 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant mouse interleukin-21 (IL-21) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, mouse interleukin-21 (IL-21) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MHKSSPQGP DRLLIRLRHL IDIVEQLKIY ENDLDPELLS APQDVKGHCE HAAFACFQKA KLKPSNPGNN KTFIIDLVAQ LRRRLPARRG GKKQKHIAKC PSCDSYEKRT PKEFLERLKW LLQKMIHQHL S

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