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RecombinantIL-22, Mouse

CAT: 0384-BK0101-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0384-BK0101-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-22 (IL-22) is a member of a group of cytokines called the IL-10 family which include IL-10, IL-19, IL-20, IL-24, and IL-26. IL-22 shares use of the IL-10R2 in cell signaling with other members of this family IL-22 signals through a receptor system consisting of IL-10R-ß/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. IL-22 is produced by activated DCs and T cells and initiates an innate immune response against bacterial pathogens especially in epithelial cells such as those in the respiratory tract and gut. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can also be produced by Th17 cells, which plays a likely role in the coordinated response of both adaptive and innate immune systems.Recombinant MouseIL-22 produced in E.coli is a single non-glycosylated polypeptide chain containing 147 amino acids. A fully biologically active molecule, rmIL-22 has a molecular mass of 16.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 98% as analyzed by SDS-PAGE& HPLC.
Bioactivity
ED50 < 0.5 ng/ml. Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells) .
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
16.8 kDa, observed by reducing SDS-PAGE
Storage Conditions
Lyophilized recombinant Mouse IL-22 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Mouse IL-22 should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM K QVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV K KLGESGEIK AIGELDLLFM SLRNACV

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