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RecombinantIL-21, Mouse

CAT: 0013-GTR18990515-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990515-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. The IL-21 receptor is highly expressed on CD4+ and CD8+ B cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21regulates the production of IgG1 and IgE by B cells, and diminishes the severity of allergy and asthma. In some cases, IL-21 induces B cell apoptosis. Other roles of IL-21 include regulation of the innate immune system, implication in autoimmunity, and antitumor activity.Recombinant mouse interleukin-21 (IL-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 123 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Product Name Alternative
Interleukin-21, IL21
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 1.0x 10ˆ6 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
15.1 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant mouse interleukin-21 (IL-21) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, mouse interleukin-21 (IL-21) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
MHKSSPQGP DRLLIRLRHL IDIVEQLKIY ENDLDPELLS APQDVKGHCE HAAFACFQKA KLKPSNPGNN KTFIIDLVAQ LRRRLPARRG GKKQKHIAKC PSCDSYEKRT PKEFLERLKW LLQKMIHQHL S

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