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Risperidone-d4-1

CAT: 0804-HY-11018S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-11018S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
Product Name Alternative
R 64 766-d4-1
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds; P-glycoprotein
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1C(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)=C(C)N=C5N1C([2H])C([2H])C([2H])C5[2H]
Molecular Formula
C23H23D4FN4O2
Molecular Weight
414.51
References & Citations
[1]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.|[2]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.|[3]Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21 (3) :259-67.|[4]Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor

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