Risperidone-d6

• Description:

  Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018) . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively[1][2].

• Product Name Alternative:

  R 64 766-d6

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor; P-glycoprotein

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C ([2H]) (C1=C (C (N2CCCC ([2H]) (C2=N1) [2H]) =O) CCN3CCC (CC3) C4=NOC5=C (C (F) =CC=C45) [2H]) [2H]

• Molecular Formula:

  C23H21D6FN4O2

• Molecular Weight:

  416.52

• References & Citations:

  [1]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  Phase 4

• Isoform:

  5-HT2 Receptor; D2 Receptor; α-1 microglobulin

• CAS Number:

  1225444-65-4