Risperidone-d6

• Description :

  Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018) . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively[1][2].

• Product Name Alternative :

  R 64 766-d6

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Dopamine Receptor; P-glycoprotein

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])(C1=C(C(N2CCCC([2H])(C2=N1)[2H])=O)CCN3CCC(CC3)C4=NOC5=C(C(F)=CC=C45)[2H])[2H]

• Molecular Formula :

  C23H21D6FN4O2

• Molecular Weight :

  416.52

• References & Citations :

  [1]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  Phase 4

• Isoform :

  5-HT2 Receptor; D2 Receptor; α-1 microglobulin

• CAS Number :

  [1225444-65-4]