Risperidone-d4

CAT: 0804-HY-110232-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-110232-01Size:500 µg
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Description
Risperidone-d4 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
CAS Number
[1020719-76-9]
Product Name Alternative
R 64 766-d4
UNSPSC
12352005
Hazard Statement
H301
Target
5-HT Receptor; Dopamine Receptor; P-glycoprotein
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.40
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
FC1=CC=C(C(C2CCN(C([2H])([2H])C([2H])([2H])C3=C(C)N=C(CCCC4)N4C3=O)CC2)=NO5)C5=C1
Molecular Formula
C23H23D4FN4O2
Molecular Weight
414.51
Precautions
H301
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.; Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.; Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.; Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21 (3) :259-67.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; D2 Receptor

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