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Imipramine-d4-1

CAT: 0804-HY-B1490AS3Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1490AS3Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imipramine-d4-1 is the deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5].
CAS Number
773801-61-9
UNSPSC
12352005
Target
Apoptosis; Autophagy; Isotope-Labeled Compounds; Serotonin Transporter
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
CN(CCCN1C2=CC=CC=C2C([2H])(C([2H])(C3=CC=CC=C31)[2H])[2H])C
Molecular Formula
C19H20D4N2
Molecular Weight
284.43
References & Citations
[1]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.|[2]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[3]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[4]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[5]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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