Risperidone (mesylate)

• Description:

  Risperidone mesylate (R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

• Product Name Alternative:

  R 64 766 mesylate

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/risperidone-mesylate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CS (=O) (O) =O.FC1=CC (ON=C2C3CCN (CCC (C (N (CCCC4) C4=N5) =O) =C5C) CC3) =C2C=C1

• Molecular Formula:

  C24H31FN4O5S

• Molecular Weight:

  506.59

• References & Citations:

  [1]Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.|[3]Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21 (3) :259-67.|[4]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT2 Receptor; D2 Receptor; α-1 microglobulin

• CAS Number:

  666179-96-0