Risperidone (mesylate)

CAT: 0804-HY-11018BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-11018BSize:1 Each
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Description
Risperidone mesylate (R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
CAS Number
[666179-96-0]
Product Name Alternative
R 64 766 mesylate
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor; P-glycoprotein
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/risperidone-mesylate.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(O)=O.FC1=CC(ON=C2C3CCN(CCC(C(N(CCCC4)C4=N5)=O)=C5C)CC3)=C2C=C1
Molecular Formula
C24H31FN4O5S
Molecular Weight
506.59
References & Citations
[1]Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.|[3]Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21 (3) :259-67.|[4]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; D2 Receptor; α-1 microglobulin

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