Risperidone (mesylate)

• Description :

  Risperidone mesylate (R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

• Product Name Alternative :

  R 64 766 mesylate

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Dopamine Receptor; P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/risperidone-mesylate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CS(=O)(O)=O.FC1=CC(ON=C2C3CCN(CCC(C(N(CCCC4)C4=N5)=O)=C5C)CC3)=C2C=C1

• Molecular Formula :

  C24H31FN4O5S

• Molecular Weight :

  506.59

• References & Citations :

  [1]Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.|[3]Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21 (3) :259-67.|[4]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT2 Receptor; D2 Receptor; α-1 microglobulin

• CAS Number :

  [666179-96-0]