Risperidone E-oxime

• Description:

  Risperidone E-oxime is an impurity of Risperidone[1]. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively [2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/risperidone-e-oxime.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C (CCN2CCC (/C (C3=CC=C (F) C=C3F) =N\O) CC2) =C (C) N=C4N1CCCC4

• Molecular Formula:

  C23H28F2N4O2

• Molecular Weight:

  430.49

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Pavel Slanina, et al. Process for making risperidone and intermediates therefor. US20040097523A1.|[2]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.|[3]Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32 (4) :757-64.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor

• CAS Number:

  691007-09-7