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Trimethoprim (sulfate)

CAT: 0804-HY-B0510ASize: 1 EachDry Ice: NoHazardous: No
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Description
Trimethoprim sulfate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim sulfate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim sulfate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim sulfate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4].
CAS Number
56585-33-2
UNSPSC
12352005
Target
Antibiotic; Antifolate; Bacterial; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/trimethoprim-sulfate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=NC=C1CC2=CC(OC)=C(OC)C(OC)=C2.O=S(O)(O)=O
Molecular Formula
C14H20N4O7S
Molecular Weight
388.40
References & Citations
[1]Laskowska, E., et al., Trimethoprim sulfate induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47 (4) : p. 286-9.|[2]Xiaojian Wang, et al. A Trimethoprim sulfate Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.|[3]Brogden, R.N., et al., Trimethoprim sulfate: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23 (6) : p. 405-30.|[4]El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18 (1) :113.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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