Trimethoprim

CAT: 0804-HY-B0510-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0510-01Size:500 mg
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Description
Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4].
CAS Number
[738-70-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Antifolate; Bacterial; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Trimethoprim.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)
Smiles
NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1
Molecular Formula
C14H18N4O3
Molecular Weight
290.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47 (4) : p. 286-9.|[2]Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23 (6) : p. 405-30.|[3]Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.|[4]El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18 (1) :113.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
RM-T181300-01Trimethoprim

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