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Trimethoprim (lactate)

CAT: 0804-HY-B0510C-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0510C-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4].
CAS Number
23256-42-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Antifolate; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/trimethoprim-lactate.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
CC(O)C(O)=O.NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1
Molecular Formula
C17H24N4O6
Molecular Weight
380.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Ewa Laskowska, et al. Trimethoprim Induces Heat Shock Proteins and Protein Aggregation in E. Coli Cells. Curr Microbiol. 2003 Oct;47 (4) :286-9.|[2]R N Brogden, et al. Trimethoprim: A Review of Its Antibacterial Activity, Pharmacokinetics and Therapeutic Use in Urinary Tract Infections. Drugs. 1982 Jun;23 (6) :405-30.|[3]Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.|[4]El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18 (1) :113.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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