Trimethoprim-d3

CAT: 0804-HY-B0510S2-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0510S2-01Size:1 mg
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Description
Trimethoprim-d3is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].
CAS Number
[1189923-38-3]
UNSPSC
12352005
Hazard Statement
H302, H361, H373, H401, H411
Target
Antibiotic; Antifolate; Bacterial
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Purity
99.24
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 0.67mg/mL (ultrasonic)
Smiles
COC(C=C1CC2=CN=C(N)N=C2N)=C(C(OC)=C1)OC([2H])([2H])[2H]
Molecular Formula
C14H15D3N4O3
Molecular Weight
293.34
Precautions
H302, H361, H373, H401, H411
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47 (4) : p. 286-9.; Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23 (6) : p. 405-30.; Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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