Trimethoprim-d3

• Description:

  Trimethoprim-d3is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H361, H373, H401, H411

• Target:

  Antibiotic; Antifolate; Bacterial

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research:

  Infection

• Purity:

  99.24

• Solubility:

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 0.67mg/mL (ultrasonic)

• Smiles:

  COC(C=C1CC2=CN=C(N)N=C2N)=C(C(OC)=C1)OC([2H])([2H])[2H]

• Molecular Formula:

  C14H15D3N4O3

• Molecular Weight:

  293.34

• Precautions:

  H302, H361, H373, H401, H411

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47 (4) : p. 286-9.; Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23 (6) : p. 405-30.; Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1189923-38-3]