BMS-795311

• Description :

  BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC50s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively[1].

• CAS Number :

  [939390-99-5]

• UNSPSC :

  12352005

• Target :

  CETP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-795311.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@@](C1=CC(OC(F)(F)C(F)F)=CC(F)=C1)(C2=CC=C(F)C(OC3CC3)=C2)CC4=CC=CC=C4)C5=CC=C(F)C(C(F)(F)F)=C5

• Molecular Formula :

  C33H23F10NO3

• Molecular Weight :

  671.52

• References & Citations :

  [1]Jennifer XQ, et, al. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[ (1R) -1- (3-Cyclopropoxy-4-fluorophenyl) -1-[3-fluoro-5- (1,1,2,2-tetrafluoroethoxy) phenyl]-2-phenylethyl]-4-fluoro-3- (trifluoromethyl) benzamide (BMS-795311) . J Med Chem. 2015 Nov 25; 58 (22) : 9010-26.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported