BMS-795311

• UNSPSC Description:

  BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC50s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively[1].

• Target Antigen:

  CETP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-795311.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@](C1=CC(OC(F)(F)C(F)F)=CC(F)=C1)(C2=CC=C(F)C(OC3CC3)=C2)CC4=CC=CC=C4)C5=CC=C(F)C(C(F)(F)F)=C5

• Molecular Weight:

  671.52

• References & Citations:

  [1]Jennifer XQ, et, al. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311). J Med Chem. 2015 Nov 25; 58(22): 9010-26.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  939390-99-5