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SB-612111

CAT: 0804-HY-18618Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-18618Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-612111 is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM) . SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].
CAS Number
[371980-98-2]
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-612111.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@@H](CN2CCC(C3=C(Cl)C=CC=C3Cl)CC2)CCC4=C(C)C=CC=C41
Molecular Formula
C24H29Cl2NO
Molecular Weight
418.40
References & Citations
[1]Paola F Zaratin, et al. Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (-) -cis-1-methyl-7-[[4- (2,6-dichlorophenyl) piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) .J Pharmacol Exp Ther. 2004 Feb;308 (2) :454-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1

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T36376-01SB-612111
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