L-Thyroxine-13C6-1

• UNSPSC Description:

  L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1][2].

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/l-thyroxine-13c6-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@H](C(O)=O)CC1=CC(I)=C(O[13C]2=[13CH][13C](I)=[13C]([13C](I)=[13CH]2)O)C(I)=C1

• Molecular Weight:

  782.83

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.|[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  1217780-14-7