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L-Thyroxine-13C6-1

CAT: 0804-HY-18341S4Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18341S4Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4)[2].
CAS Number
1217780-14-7
Product Name Alternative
Levothyroxine-13C6-1; T4-13C6-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-thyroxine-13c6-1.html
Solubility
10 mM in DMSO
Smiles
N[C@H](C(O)=O)CC1=CC(I)=C(O[13C]2=[13CH][13C](I)=[13C]([13C](I)=[13CH]2)O)C(I)=C1
Molecular Formula
C9 13C6H11I4NO4
Molecular Weight
782.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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