L-Thyroxine-13C6-1

L-Thyroxine-13C6-1

• CAS Number: 1217780-14-7
• UNSPSC Description: L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1][2].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/l-thyroxine-13c6-1.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@H](C(O)=O)CC1=CC(I)=C(O[13C]2=[13CH][13C](I)=[13C]([13C](I)=[13CH]2)O)C(I)=C1
• Molecular Weight: 782.83
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.|[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported