L-Thyroxine (sodium)

• Description:

  L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [1].

• Product Name Alternative:

  Levothyroxine (sodium) ; T4 (sodium)

• UNSPSC:

  12352005

• Hazard Statement:

  H361, H372

• Target:

  Endogenous Metabolite; Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/l-thyroxine-sodium.html

• Concentration:

  10mM

• Purity:

  99.75

• Solubility:

  0.5 M NaOH : 25 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C) |DMSO : 62.5 mg/mL (ultrasonic) |H2O : 14 mg/mL (ultrasonic; adjust pH to 12 with NaOH)

• Smiles:

  N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O

• Molecular Formula:

  C15H10I4NNaO4

• Molecular Weight:

  798.85

• Precautions:

  H361, H372

• References & Citations:

  [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• Citation 01:

  J Drug Deliv Sci Technol. 2023 Sep 28, 105008.|Cell Rep Med. 2023 Jun 20;4 (6) :101061.|Dis Model Mech. 2024 Aug 14:dmm.050748.|EMBO J. 2024 Aug;43 (15) :3090-3115.|Mol Brain. 2021 Jan 27;14 (1) :25.|Nat Immunol. 2024 Apr;25 (4) :659-670.|Sci Rep. 2022 Jul 4;12 (1) :11259.|Stem Cell Rev Rep. 2021 Jun;17 (3) :999-1013.

• CAS Number:

  [55-03-8]