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L-Thyroxine (sodium)

CAT: 0804-HY-18341B-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18341B-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [1].
CAS Number
55-03-8
Product Name Alternative
Levothyroxine (sodium) ; T4 (sodium)
UNSPSC
12352005
Hazard Statement
H361, H372
Target
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/l-thyroxine-sodium.html
Concentration
10mM
Purity
99.75
Solubility
0.5 M NaOH : 25 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C) |DMSO : 62.5 mg/mL (ultrasonic) |H2O : 14 mg/mL (ultrasonic; adjust pH to 12 with NaOH)
Smiles
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O
Molecular Formula
C15H10I4NNaO4
Molecular Weight
798.85
Precautions
H361, H372
References & Citations
[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
J Drug Deliv Sci Technol. 2023 Sep 28, 105008.|Cell Rep Med. 2023 Jun 20;4 (6) :101061.|Dis Model Mech. 2024 Aug 14:dmm.050748.|EMBO J. 2024 Aug;43 (15) :3090-3115.|Mol Brain. 2021 Jan 27;14 (1) :25.|Nat Immunol. 2024 Apr;25 (4) :659-670.|Sci Rep. 2022 Jul 4;12 (1) :11259.|Stem Cell Rev Rep. 2021 Jun;17 (3) :999-1013.

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