L-Thyroxine-13C6

CAT: 0804-HY-18341S2Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-18341S2Size:100 µg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
L-Thyroxine-13C6 is the 13C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [2].
CAS Number
[720710-30-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-thyroxine-13c6.html
Purity
91.0
Solubility
10 mM in DMSO
Smiles
IC(C=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13C]2I)C[C@H](N)C(O)=O)I)=C(C(I)=C1)O
Molecular Formula
C9 13C6H11I4NO4
Molecular Weight
782.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 92 (4) :144-149.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Popular Products