L-Thyroxine-13C6

L-Thyroxine-13C6

• CAS Number: 720710-30-5
• UNSPSC Description: L-Thyroxine-13C6 is the 13C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[2].
• Target Antigen: Endogenous Metabolite; Thyroid Hormone Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/l-thyroxine-13c6.html
• Purity: 91.0
• Solubility: 10 mM in DMSO
• Smiles: IC(C=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13C]2I)C[C@H](N)C(O)=O)I)=C(C(I)=C1)O
• Molecular Weight: 782.83
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 92(4):144-149.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported