Biotin- (L-Thyroxine)

• Description:

  Biotin- (L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341) . L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from Biotin- (L-Thyroxine) (T4) [1].

• UNSPSC:

  12171500

• Target:

  Endogenous Metabolite; Thyroid Hormone Receptor

• Type:

  Dye Reagents

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/biotin-l-thyroxine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  IC(C=C1C[C@@H](C(O)=O)NC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=C(C(I)=C1)OC4=CC(I)=C(C(I)=C4)O

• Molecular Formula:

  C25H25I4N3O6S

• Molecular Weight:

  1003.17

• References & Citations:

  [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [149734-00-9]