L-Thyroxine

• UNSPSC Description:

  L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].

• Target Antigen:

  Endogenous Metabolite; Thyroid Hormone Receptor

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/l-thyroxine.html

• Purity:

  99.49

• Solubility:

  1M NaOH : 5 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)|DMSO : 233.33 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O)=O

• Molecular Weight:

  776.87

• References & Citations:

  [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.Cell Rep Med. 2023 May 24;101061.|Dis Model Mech. 2024 Aug 14:dmm.050748.|EMBO J. 2024 Jun 5.|Mol Brain. 2021 Jan 27;14(1):25.|Nat Immunol. 2024 Mar 18.|Sci Rep. 2022 Jul 4;12(1):11259.|Stem Cell Rev Rep. 2021 Jun;17(3):999-1013.|J Drug Deliv Sci Technol. 2023 Sep 28, 105008.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  51-48-9