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Thyroxine hydrochloride-13C6

CAT: 0804-HY-18341S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18341S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thyroxine hydrochloride-13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [1].
CAS Number
1421769-38-1
Product Name Alternative
Levothyroxine-13C6; T4-13C6
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/thyroxine-hydrochloride-13c6.html
Solubility
10 mM in DMSO
Smiles
IC(C=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13C]2I)C[C@H](N)C(O)=O)I)=C(C(I)=C1)O.Cl
Molecular Formula
C9 13C6H12ClI4NO4
Molecular Weight
819.29
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

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CS-O-14503Thyroxine-13C6
TMID-0104-01L-Thyroxine-13C6
BISC1052L-Thyroxine-[L-Tyr-ring-13C6] hydrochloride
sc-491252β-Hydroxy Thyroxine-13C6
sc-491000N-Formyl Thyroxine-13C6
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