Thyroxine hydrochloride-13C6

Thyroxine hydrochloride-13C6

• CAS Number: 1421769-38-1
• UNSPSC Description: Thyroxine hydrochloride-13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/thyroxine-hydrochloride-13c6.html
• Solubility: 10 mM in DMSO
• Smiles: IC(C=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13C]2I)C[C@H](N)C(O)=O)I)=C(C(I)=C1)O.Cl
• Molecular Weight: 819.29
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[3]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported