TBAJ-587

• Description :

  TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and [1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/TBAJ-587.html

• Purity :

  99.69

• Solubility :

  DMSO : 43.33 mg/mL (ultrasonic)

• Smiles :

  COC1=C(F)C([C@H](C2=CC3=CC(Br)=CC=C3N=C2OC)[C@](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=CC=C1

• Molecular Formula :

  C30H33BrFN3O5

• Molecular Weight :

  614.50

• References & Citations :

  [1]Sutherland HS, et al. 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorg Med Chem. 2019 Apr 1;27 (7) :1292-1307.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2252316-16-6]