TBAP-001

• Description :

  TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay[1].

• UNSPSC :

  12352005

• Target :

  Raf

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tbap-001.html

• Concentration :

  10mM

• Purity :

  99.81

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=CC(F)=C2)NC3=CC=C(OC4=C(N=C5)C(NC5=O)=NC=C4)C=C3F

• Molecular Formula :

  C27H23F2N7O3

• Molecular Weight :

  531.51

• References & Citations :

  [1]Caroline Joy, et al. 1 - (5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL) -3-[2-FLUORO-4-[ (3-OXO-4H-PYRIDO[2

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1777832-90-2]