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DHFR-IN-15

CAT: 0804-HY-161064Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161064Size:1 Each
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Description
DHFR-IN-15 (compound 34) is a dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity. DHFR-IN-15 effectively binds to DHFR in cells, reducing DHFR levels to 10 nM[1].
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhfr-in-15.html
Solubility
10 mM in DMSO
Smiles
CN(C1=CC=C(C2=C(N)N=C(N)N=C2)C=C1[N+]([O-])=O)CC3=CC=CC=C3
Molecular Formula
C18H18N6O2
Molecular Weight
350.37
References & Citations
[1]Brown JI, et al. Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens. Eur J Med Chem. 2024 Jan 15;264:115971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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